22M, severe depression + DPDR, multiple medication trials. Amisulpride helped a lot initially but stopped working. What diagnosis and next medication would you consider?
Hi, I’m 22M and I’m posting here because I’d really appreciate an opinion from psychiatrists who have experience with difficult or treatment resistant cases.
I’ve been struggling with depression, anxiety and pretty severe depersonalization/derealization for quite a while.
The depression is probably the biggest problem for me. There are periods where I become extremely depressed, emotionally numb, completely unmotivated and exhausted. I lose interest in almost everything and it becomes very difficult to concentrate or even think properly. Sometimes I feel completely empty and disconnected from myself and other people.
The DPDR is also pretty strong. I often feel detached from myself and my surroundings, like I’m there physically but not really experiencing things normally. It can make everything feel unreal and distant.
My mood also seems to fluctuate quite a bit. I can have periods of around 5 to 10 days where the depression becomes extremely intense, and then I can suddenly start feeling significantly better. Sometimes these better periods last several days or even a few weeks before things deteriorate again.
I’m not sure what to make of this pattern and whether it points toward a particular diagnosis or whether it can still happen with major depression.
I’ve tried quite a few medications:
Escitalopram
Amisulpride
Aripiprazole
Bupropion
Lithium carbonate
Vortioxetine
Lamotrigine, for around 6 to 8 months
Sertraline
Desvenlafaxine
Clonazepam, short term
The medication that has stood out the most for me has been amisulpride.
When I first started taking it, I felt dramatically better. I was taking around 20 to 50 mg and the improvement was honestly much more noticeable than anything I had experienced with the other medications.
Unfortunately, after around two months, the effect seemed to fade.
I’m still taking it because I feel that it helps me more than most of the other medications I’ve tried, but it definitely doesn’t feel anything like it did initially.
I’ve also actually done CBT with a psychologist for several weeks. It wasn’t just a couple of sessions either. There was quite a lot of therapy and work involved.
She specifically told me that I have Cluster B traits. I’m not completely sure what she meant by that though. I don’t know whether she meant that I have traits associated with a specific Cluster B personality disorder or whether she thought I had some traits without meeting the full criteria for a personality disorder.
I’m mentioning this because I’m wondering if it could be relevant to the overall picture.
I don’t currently have suicidal thoughts or a plan, but during the really bad periods the depression can become extremely intense.
At this point I’m honestly confused about what my actual diagnosis is.
Would this history be considered treatment resistant depression?
Does the pattern of my mood changes suggest that something other than straightforward unipolar depression should be considered?
Could the DPDR and the Cluster B traits be part of a larger underlying picture rather than separate problems?
And most importantly, if you were seeing a patient with this history, what would you consider doing next?
Are there particular diagnoses you would want to rule out first?
And after so many medication trials, what medication or treatment strategy would you personally consider discussing with the patient next?
I’m not asking for someone to prescribe something to me over Reddit or for me to change anything without my psychiatrist. I’m mainly trying to get a professional perspective on what diagnosis might fit this pattern and what reasonable next steps I should discuss with my psychiatrist.
I’d really appreciate an honest psychiatric opinion, even if the answer is that my current understanding of what’s going on is completely wrong.
Thanks for reading.