I wanted to share my experience in case it helps even one person who finds themselves in a similar situation.
At the beginning of January, I suddenly developed what was eventually diagnosed as inverse psoriasis in a very sensitive area. I had dealt with tiny psoriasis patches behind my ears and occasionally around my eyebrows before, especially during the winter, but they were never a major issue. Oatmeal lotion was usually enough to clear them.
What happened this year was completely different.
Because of where the psoriasis was located, it affected my comfort, sleep, confidence, and quality of life in a way I had never experienced before. I dealt with redness, itching, cracking, sensitivity, TERRIBLE nighttime itching, and irritation from normal everyday activity. It started making me extremely depressed.
Over the following months I went through multiple diagnoses and treatments. I tried RX strength hydrocortison, tacrolimus, pimecrolimus, and Zoryve (roflumilast). I was also prescribed VTAMA (tapinarof) but ultimately decided not to use it because I was nervous about the potential side effects I read about. Zoryve did help a lot, but I seemed permanently stuck at maybe 70–80% better. I could never get completely back to normal.
Eventually I went through just about everything I was taking and eating with ChatGPT, trying to figure out whether I was missing something. GPT came back stating two medications I was taking could be factoring into my condition:
Ibuprofen: I had been taking around 600–800 mg almost every day for months because of chronic back pain.
Propranolol: I was taking 20–30 mg roughly 3–5 times a week off-label for anxiety.
Both NSAIDs and beta blockers have been reported to aggravate psoriasis in some people. I had absolutely NO IDEA.
Around the same time, my dermatologist wanted me off Zoryve for two weeks before an appointment so she could see what my psoriasis looked like untreated. We were getting to the point where I was seriously considering Skyrizi because I felt like topical treatment had reached its limit.
So I stopped Zoryve.
I also stopped the ibuprofen and propranolol after considering the medication connection.
And then…
Instead of getting worse without Zoryve, I started getting better. Almost immediately.
The nighttime itching disappeared. The redness started fading. The constant inflammation settled down. The skin gradually started looking and feeling normal again.
I kept waiting for the flare to come roaring back.
It never did.
It has now been 3 months without Zoryve, ibuprofen, propranolol, or any other psoriasis treatment, and I am essentially 100% clear. I’m not waking up itching. I’m not dealing with constant sensitivity or irritation anymore. I’m not obsessively checking the skin. I finally feel normal again.
After everything I went through this year, it genuinely feels like a miracle.
Obviously this is just my experience, and I am NOT saying everyone with psoriasis should stop their medications (Definitely not without consulting your Dr.’s)
But I wanted to make this post as a PSA:
If you have stubborn psoriasis that refuses to fully respond to treatment, take a look at every medication you’re taking and ask your dermatologist whether any of them could be aggravating it.
In my case, I spent months trying stronger and stronger psoriasis treatments without realizing that something I was taking for completely unrelated issues may have been continually fueling the inflammation.
I don’t know whether ibuprofen, propranolol, or the combination was the main culprit. I’ll never know for sure. BUT the timing of stopping them and then going into remission, even while simultaneously stopping my psoriasis medication, has been pretty remarkable.
I really hope this helps somebody else.