I know this is probably buried somewhere else in this thread...but I'm just trying to make sure this is the same...don't come for me.

I was previously on 7.5 mounjaro, I stopped it when I started Reta. I'm on week 6 of Reta and haven't really noticed anything. Is it too soon to combine the two? Can I combine the two? What doses have you heard of others stacking with the two? Did I start on a dose that is too low because I was on Mounjaro? HELP LOL.

Hello, I have been on Reta for 15 weeks now. I lost 8 kg from 112 to 104 kg. However, I noticed that my weigh loss is slower now (0.5 kg/week vs previous 1 kg/week.) I do weight training and walking. Calorie deficit at 1500 cal/day. Is there anything I can do to speed up the weight loss? I'm been on 5 mg for a month. Thanks

Mod offer: GLPzy Lifetime Premium free until 31 August

I haven’t really offered GLPzy here, but as the free Lifetime offer finishes on 31 August I thought I’d put it up once. Generally I my other activities separate to here but it felt amiss to offer it elsewhere and not to this growing sub.

I’m the creator of GLPzy as well as the mod here. I originally built it for myself and it’s now getting very close to 10,000 downloads.

It tracks doses, weight, symptoms, food noise, injection sites, supply and progress, with custom dosing as well. Reta is listed as an Investigational medicine so a little tucked away until official licensing comes through, but is otherwise works the same as any other medicine or compounding in the app.

Lifetime Premium is $0 until 31 August. Claim it once and it from Settings and it stays unlocked forever and any future features will come for free too.

https://apps.apple.com/app/id6761775005

If anyone here uses it, feedback is always useful. To be upfront it’s a general tracking app, and doesn’t offer any pep calculations. I think there are other tools out there for that.

Web: https://www.glpzy.app

It is Progress Friday.

Share whatever progress you want to celebrate this week.

Photos are welcome, but so are scale changes, waist changes, clothes fitting differently, appetite settling, food noise easing, energy improving, fitness getting easier, blood markers moving, confidence coming back, or just a small habit you kept going.

Big changes, small changes, early days, long journeys, all welcome.

This is a weekly place to mark what is moving in the right direction and cheer each other on.

This study is doing the rounds. Says 7.2% weight loss for grey Reta, vs 15.5% in the trials and 7.7% matched tirzepatide.

But:

Only about a third actually had a Reta start date. Rest they just used first mention in medical record.

Use was 56 days, follow up around 130 days. So not exactly people followed cleanly for 6-12 months.

They dont know dose, titration or really what people were taking. Some may have used GLP-1s before too and that wouldnt necessarily be in the record.

Baseline BMI was pretty similar across groups, around 32-34. So doesnt really look like grey users simply had less weight to lose, at least from that.

Heart rate was up, which we already know can happen with Reta.

CV events were tiny numbers though and not statistically significant.

I dont think the study is useless, actually quite interesting seeing any real world grey Reta data - is a first?

Just not sure the 7.2% headline really tells us that much.

Those here on Reta 6+ months how does that compare?

Study:

https://www.preprints.org/manuscript/202608.1193

It is Research Wednesday.

Share any Retatrutide or challenger study, trial update, article, presentation or useful piece of research you have found this week.

It does not need to be brand new but should be within the 2 months not already shared, and it does not need to be highly technical. A useful summary, an interesting result, a question about a paper, or something you think deserves more attention is welcome.

This can also include wider obesity drug research where it helps explain where retatrutide fits.

What have you read or learned this week?

Personally I still like a drink and haven't noticed a substantial change. I see many report on GLP-1s saying they drink less, don’t enjoy alcohol as much, can't drink it, or just don’t think about it in the same way. I think evidence this year is getting stronger that there is an impact for quite a number:

In 2022, 127 people with alcohol use disorder were randomised to exenatide or placebo for 26 weeks. It didn’t reduce heavy drinking days compared with placebo, which was the main endpoint. Only 58 people completed the full trial.

A JAMA Psychiatry study published in February 2025 randomised 48 people to semaglutide or placebo. Semaglutide reduced alcohol consumed in a laboratory test, as well as craving and some measures of drinking outside the lab. It was small though, and only 25 people were included in the main post-treatment laboratory analysis.

SEMALCO was published in The Lancet in May 2026. It included 108 people with obesity and moderate or severe alcohol use disorder. They received semaglutide 2.4 mg or placebo for 26 weeks, with CBT in both groups.

Heavy drinking days fell by 41.1 percentage points with semaglutide and 26.4 points with placebo. The difference between the groups was 13.7 points, p=0.0015.

It was randomised and double-blind, but still only 108 people, at one centre, and everyone in the trial had obesity.

Another trial published on 29 July used oral semaglutide in 50 people.

It didn’t significantly improve the main craving measure. Drinks per day also narrowly missed statistical significance at p=0.057. Heavy drinking days did improve, p=0.008, as did drinks per drinking day. 47 of the 50 people completed the trial.

Pemvidutide reported results in July as well. It activates GLP-1 and glucagon receptors, so it overlaps with two of Reta’s three targets.

100 people with alcohol use disorder were treated for 24 weeks. Compared with placebo, heavy drinking fell by another 1.45 days per week. 64.4% improved by at least two WHO drinking-risk levels compared with 34.8% on placebo. 42.2% had no heavy drinking days in the final four weeks compared with 17.4%.

PEth, a blood marker of recent alcohol consumption, also fell.

Those pemvidutide results are still company topline results rather than a full peer-reviewed paper.

A Swedish observational study of 227,866 people with alcohol use disorder also found semaglutide use was associated with about a 36% lower risk of hospitalisation for alcohol-related problems. It wasn’t randomised, so it can’t show that semaglutide caused the difference.

No studies directly on reta as far as I aware (yet). Did Reta make any material difference for you?

10mg to 1ml pinned 6 units. Felt horrible for the first 24 hours! Feeling better today. Kinda scared to repeat dose! I was thinking maybe this isn’t for me! would you recommend less for next pin? and how often should I use? I was told every 5 days..

A new week, so what is one thing you want to move forward?

It could be getting back into a routine, improving protein or hydration, walking more, doing some strength work, tracking properly, preparing better meals, sleeping better, dealing with a side effect, or simply keeping going.

It does not need to be a big target. Pick one thing that would make this feel like a good week.

Share yours below, and come back later in the week if you want to say how it went.

I’m currently on tirzepatide and honestly have zero complaints. I’ve had essentially no side effects, appetite control has been great, and it’s working for me.

But I keep seeing more and more about retatrutide, and know personally several people who have switched and I’m curious why someone would choose Reta over tirz, especially if tirz is already working well.

I’m 6’0”, 34 years old, currently around 184 lbs. I’d estimate I’m somewhere around 25% body fat, give or take a few percentage points. I’m not that far from what I consider my goal weight, but I still probably have another 10 to 15 percentage points of body fat I’d like to lose.

At this point I’m basically approaching this as a body recomposition rather than just trying to make the scale go down. I’m planning to cut for another 6 months to a year, probably closer to a year, because I’ve got a decent amount of fat around my stomach and chest that I want to slowly work off while maintaining as much muscle as possible.
I’m currently eating roughly 1,500 to 2,000 calories per day and lifting/working out 3 to 5 days per week depending on recovery and how my injured back is feeling.

So for people who have actually researched or used both:

\*\*Why would you choose retatrutide over tirzepatide?\*\*

Is Reta meaningfully better for someone who is already relatively close to their goal weight and is trying to get leaner while preserving muscle?
I know the Reta trials have shown some pretty impressive weight loss, but I’m more interested in the differences beyond just total pounds lost. Things like body composition, fat loss vs lean mass, appetite control, energy, metabolic effects, and whether people actually notice a meaningful difference compared with tirz.

I’m not looking to switch just because something is newer. If tirz is already working extremely well, I’m wondering what the actual advantage of Reta would be for someone in my situation.

Would love to hear from people who have experience with both, or anyone who has dug deeply into the clinical data.

Added a picture of what I look like currently a week ago.

It is Progress Friday.

Share whatever progress you want to celebrate this week.

Photos are welcome, but so are scale changes, waist changes, clothes fitting differently, appetite settling, food noise easing, energy improving, fitness getting easier, blood markers moving, confidence coming back, or just a small habit you kept going.

Big changes, small changes, early days, long journeys, all welcome.

This is a weekly place to mark what is moving in the right direction and cheer each other on.

A lot has happened in the space over the last week.

August 18: Reports started coming in that multiple peptide-related Discord servers had been shut down. At least one individual server removal has been separately reported, although there’s no public confirmation from Discord that this is a coordinated reta-specific enforcement wave.

August 17: Two prominent peptide creators, Josh Holyfield and Trevor Bachmeyer, lost their YouTube channels. Holyfield says directly that YouTube took his channel down. Bachmeyer’s channel has also disappeared, although I haven’t seen a statement from him or YouTube explaining why.

August 12: Eli Lilly filed six new lawsuits against US businesses selling retatrutide — covering a medical spa, pharmacy and online peptide sellers.

That part is much bigger than six lawsuits.

Lilly says it has now:

• referred 200+ individuals and entities to the FDA, DOJ, state attorneys general, law enforcement and professional licensing boards
• reported 14,000+ websites, advertisements, social-media posts and product listings
• done so across 100+ countries
• explicitly called on social-media and e-commerce platforms, credit-card companies, payment processors, and shipping/logistics companies to cut off the infrastructure supporting grey-market retatrutide sales

The six defendants are Aesthetic Envy, Astra Peptides, Legendary Peptides, Striker Pharmacy, Texas Peptides and Lone Star Peptide.

Taken together, this is starting to look less like a handful of lawsuits against individual vendors and more like pressure being applied across the wider ecosystem that allows the grey market to operate.

The important distinction is that Lilly’s legal action and requests to platforms are confirmed. The timing of the YouTube and Discord removals is also notable, but there’s currently no public evidence showing that Lilly directly requested those specific takedowns.

Personally I’m very interested in maintenance research as I’m 65% on the way to it on my weight loss and have the open question what’s next apart from a lifetime of a maintenance dose, accept some regain, or being able to wean off and hold healthier habits.

The headlines are a bit “exercise pill” but ENV-308 has finished its first human trial in 88 healthy adults

It’s a once-daily pill based on Lac-Phe, a molecule the body produces during intense exercise.

No serious adverse events, no discontinuations or dose interruptions, and few GI problems were reported.

There’s no human weight-loss data yet. This was mainly a safety trial.

Enveda now plans to test it in people coming off GLP-1 treatment to see whether it can stop weight coming back.

In animal studies, the company says ENV-308 prevented weight regain after treatment stopped and preserved lean mass so back to my first point, quite interesting.

Original Lac-Phe paper:
https://www.nature.com/articles/s41586-022-04828-5

Im 6 weeks on reta, I've lost 12 pounds. Started at 2mg, no side effects. Week 5 increased to 4mg and I've had terrible diarrhea ever since. Idk what to do, I feel terrible! No energy. Do I just have to deal with this or will it get better?

It is Research Wednesday.

Share any Retatrutide or challenger study, trial update, article, presentation or useful piece of research you have found this week.

It does not need to be brand new but should be within the 2 months not already shared, and it does not need to be highly technical. A useful summary, an interesting result, a question about a paper, or something you think deserves more attention is welcome.

This can also include wider obesity drug research where it helps explain where retatrutide fits.

What have you read or learned this week?

500 already. That went quickly 😊

It was only 7 days ago we hit 400, so that’s 25% growth in a week. It’s only a few weeks since 200 members milestone too.

Really good to see how much more active it’s getting. More questions, progress posts, people sharing what they’re finding and a lot more discussion in the comments.

I’m going to post a bit less and keep moderation pretty light. The main exception is sourcing, which will stay a hard rule. Any uncertainty if a post is OK then modmail to check.

Thanks to everyone posting, commenting and helping other people out.

1,000 next. I think we’ll get there sooner than I expected.

Tell the community a good news story!

1. Starting weight:

2. Current weight:

3: How many kgs/lbs lost (to save doing the math of 2-1 😉):

4: Timeframe (months):

1. Current dose:

6: Tips/tricks (exercise, no exercise, cardio, weights, calorie counting, steps etc):

Post your amazing stories and inspire!

A new week, so what is one thing you want to move forward?

It could be getting back into a routine, improving protein or hydration, walking more, doing some strength work, tracking properly, preparing better meals, sleeping better, dealing with a side effect, or simply keeping going.

It does not need to be a big target. Pick one thing that would make this feel like a good week.

Share yours below, and come back later in the week if you want to say how it went.

I inject Zepbound every week, so I understand the retatrutide FOMO. Reta is Eli Lilly's triple agonist, the next molecule up from tirzepatide, still in Phase 3 trials and approved nowhere in the world. That is what got me looking at where people actually buy it.

Sam Sulek, one of the biggest fitness YouTubers, says on camera that he co-owns a peptide company called NewBioRx. The storefront sold a $285 pre-filled retatrutide pen under the standard research-chemical disclaimer: "Bodily introduction of any kind into humans or animals is strictly prohibited by law." A second website carrying the NewBioRx logo published a milligrams-to-units conversion table for that pen and a twelve-photo walkthrough titled "How To Give Yourself a Shot." One site swore no human may ever use the product. The other assumed a human was using it.

The timing matters. On August 12, Eli Lilly sued six US sellers of retatrutide, and its complaints lean on exactly this kind of material, the dosing calculators and injection guides, as evidence that a "research use only" label is a fiction. NewBioRx is not one of the six defendants, and nobody has sued Sulek's company. It is the same pattern, though. The FDA has separately said retatrutide cannot legally be used in compounding at all.

Then, on Sunday afternoon, while I was finishing the write-up, the pen's product page went 404 and the entire instructions site was replaced by a NewBioRx-branded "Coming soon" page. The 16 mg and 30 mg vials are still for sale. I don't know who took the pages down or why. I had archived everything first, and the write-up links to the archives.

I documented the whole paper trail, the product pages, the instructions site, the corporate filings, and Sulek's own on-camera explanation that research-only products are not "held to the same quality standards" as FDA-regulated ones, with screenshots: full write-up on my blog with the details.

The disclaimer itself is what bothers me most. It does not describe the product, and the seller's own instructions contradicted it. Its practical effect is that when something goes wrong, the person holding the pen owns the outcome, not the company that sold it. I think that is the real product being sold: deniability. Curious whether anyone here reads "research use only" differently.