r/blueprint_ Jan 25 '26

Bryan's Updated 2026 Protocol

138 Upvotes

“Hi friends,

We might be the first generation that doesn't die. To that end, my team and I have spent the last few years building the world's first Don't Die protocol.

Some of you don't care about Don't Die, you just want to be hot. That's cool too. It's really the same thing.

To make this Don't Die thing understandable, I've made it into a game because humans love games. You'll learn how to flex your biomarkers with friends. You'll be able to share the science with friends on why poor sleep is a terrible idea.

Personally, I have kind of taken this whole thing to the extreme. There's the world's fastest person, and the richest, but never before has there been the "Healthiest Person in the World."

I've tried to become that person. I am certainly the most biologically measured person ever.

Online, people refer to me as "immortal unc." That's what we care about. We are family and we care about your well-being. In fact, I want to be the strongest voice in your mind encouraging you to make health your top life priority.

To remind you that you will be a better father, mother, brother, sister, friend, colleague, and human when you do so.

If you're new to this game of health, don't worry. I made disastrous health decisions in life until I was 42 and my body has bounced back. No matter your situation, you can too.

Below I'm going to share everything my team and I have learned over the past few years, spending millions of dollars researching, experimenting and measuring. We've made the mistakes for you.

Know that we are also hard at work to make all of this easier, more accessible and fun.

We are living in the most exciting time in human history. The future is probably cooler than anything we can imagine. Our goal is to get there, together.

Don't Die,

Bryan Johnson

Planet Earth, 2026”

--

Full Protocol: https://blueprint.bryanjohnson.com/blogs/news/bryan-johnsons-protocol


r/blueprint_ Oct 28 '25

Blueprint just raised $60M to bring Bryan's longevity protocol to everyone

157 Upvotes

Hey All!

Big news dropped today that I wanted to share with you all: Blueprint just closed a $60 million funding round.

TLDR: Bryan Johnson's longevity protocol is about to become accessible to the general public through a comprehensive platform. This could be a pretty significant moment for the biohacking/longevity space.

They're building out a full-service platform that includes:

  • Blood testing and biomarker tracking
  • Personalized health protocols
  • Food delivery, GLP-1 access, prescription services
  • At-home testing, toxin screening
  • Skin/hair care products
  • Supplements and nutrition
  • Advanced longevity therapies
  • An AI health companion to tie it all together

Basically trying to make Bryan's entire protocol - measurements, therapies, protocols - replicable for everyone at different budget and commitment levels with more personalization.

The team:

Gyre Renwick (ex-President of Modern Health, previously at Google Health and Lyft Healthcare) is coming on as CEO. Bryan will focus on vision/strategy while Gyre runs operations.

Investor list is pretty wild:

Tech: Andrej Karpathy (ex-OpenAI/Tesla), John Carmack, Drew Houston (Dropbox), Emmett Shear (ex-Twitch)

Crypto: Winklevoss twins, Balaji Srinivasan, Naval Ravikant

Others: Kim Kardashian, Logan Paul, Jay Shetty, and a bunch more

They're hiring: CTO, CPO, Chief Medical Officer, CMO, plus engineers. Open roles linked in post.

My take:

Whether you're a Blueprint skeptic or believer, this is one of the most well-funded attempt yet to make evidence-based longevity protocols mainstream. The investor list suggests they're serious about scale.

What do you all think? What would you like to see the team build with this new investment?

(https://www.linkedin.com/posts/bryanrjohnson_blueprint-raises-60-million-activity-7389007282996621312-7-g_?utm_source=share&utm_medium=member_ios&rcm=ACoAABnurTMBqnu740cHvSyjt4HpobGaZ8P_Jyw)

(Written by a Human, Formatted by AI)


r/blueprint_ 13h ago

Does anyone know how much Cocoa is in Longevity protein?

3 Upvotes

Ingredients state, “cocoa powder”, yet it doesn’t mention the actual amount of Cocoa in the powder itself.


r/blueprint_ 1d ago

I just collected 10k glucose measurements for female health…

57 Upvotes

I’m collecting 10,000 glucose measurements across my menstrual cycle… 

  • I eat the same thing 
  • wear a CGM 24/7 
  • track my hormones daily

We’ll see how my body handles the same food differently

Here's why…

During this experiment:

+ I eat the same meals
+ same portions
+ every calorie counted 
+ chosen by a medical team 

By keeping my food fixed, we will be able to track changes that are caused by my hormones fluctuating (and not by food). 

This sensor lives in my arm 24/7.

It fires a tiny needle into my body and instantly retracts it… leaving behind a soft, flexible filament about 5mm long. 

Its tip is coated with an enzyme that reacts with glucose, and that reaction creates a tiny electrical current.

More glucose = more current.

The sensor converts that current into a glucose reading every 5 minutes, collecting ~10,000 per cycle.

It's called a continuous glucose monitor (CGM). 

What does this mean for women?

The best study to date (49 women) found glucose runs around 5% higher in the two weeks after ovulation.

If the pattern is real and measurable, it means the same breakfast can hit your body differently each week…

For women near the diabetic threshold, food choices carry extra weight in the two weeks after ovulation… the same meal lands on a body that's already working harder. And among diabetic women of reproductive age, almost 1 in 3 don't know it. 

I am just finishing my first full cycle… it is in data analysis now.

My second cycle starts in the coming days.

We’re asking questions like…

+ Did my glucose rise before my period?
+ How did my lipids change? 
+ Did this predict any other changes? 

If you're new here:

I am becoming the world's most measured woman. Essentially the female equivalent of Bryan Johnson (my boyfriend).

We're spending $2.6m collecting 14 million data points on my menstrual cycle… because female health is desperately understudied.

We'll share everything here, the wins and the failures, so follow along to find out what happens. 


r/blueprint_ 1d ago

Adults aged 40 and older performed about 12% faster on a test of executive function after using a HEPA air purifier at home for one month.

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18 Upvotes

Great reminder for why Bryan puts so much emphasis around air quality.


r/blueprint_ 1d ago

My Subscription and supplements - feedback please!

5 Upvotes

Hi there

just looking for feedback on my subscription.

So every 3 months I get:

  • 30 day supply of Omega 3
  • 90 day supply of advanced anti-oxidants
  • 1 bottle of EVOO
  • 30 day longevity mix
  • 90 day suply of essential capsules

I also take 2mg of chialis most days.

any feedback welcome, particularly if you think i can cancel some of the above (e.g. if it overlaps) or how I should take it each day.

many thanks!


r/blueprint_ 1d ago

How can one take vitamin D from sunlight while minimising skin damage?

8 Upvotes

I have learned that the optimum intake requires spending some period of time in afternoon sun to recieve UV B rays with skin exposed. This time window will vary skin tone to skin tone. A valid alternative is to take oral/injection supplement.

But let's say that you want to go for sunlight absorption then how would you do it? Such as, you could cover your face to save face from damage as skin is thinnest and it ages fastest in that area. What else would you do?


r/blueprint_ 1d ago

Why doesn't Bryan use Cacao powder (raw powder of cocoa fruit) in Green Giant instead of undutched cocoa powder?

8 Upvotes

Cacao powder retains more nutrition than cocoa powder due to minimal heat.

Also, it is not very clear to me if Bryan takes cacao but calls it undutched cocoa powder or if the two are different. If someone could clarify this, it would be helpful.


r/blueprint_ 1d ago

What is one's right to Vitamin D?

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0 Upvotes

r/blueprint_ 1d ago

For the supplement tablets Bryan takes, what are some natural sources with same contents (even in lower doses)?

1 Upvotes

Not going for synthetic origin supplements.


r/blueprint_ 2d ago

Exercise Keeps Mitochondria Young Deep Into Old Age, With One Exception That May Matter Most.

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40 Upvotes

r/blueprint_ 2d ago

21M just got Phenotypic Age results — 44.23 vs chronological 21.06 (23 year gap). Is this reversible? Willing to do whatever it takes.

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7 Upvotes

Hey everyone, I need some serious advice, a reality check, and a battle plan. I’m a 21-year-old male, and I recently ran my comprehensive blood work through the Morgan Levine PhenoAge calculator. The result completely terrified me: it says my biological age is 44.23 years old (a +23 year difference).

I am highly motivated, willing to work incredibly hard, and ready to do whatever protocol is necessary to fix this. But first, I need to know if this is actually reversible or if I'm just being penalized by the algorithm for a few skewed hematological markers.

The PhenoAge Inputs

Albumin: 3.51 g/dL (Low-normal, penalizing me)

Creatinine: 1.0 mg/dL (Optimal)

Glucose: 81 mg/dL (Optimal)

hs-CRP: 1.0 mg/L (Estimated/Guessed, wasn't on the panel)

Lymphocyte %: 18.2% (Normal, but algorithm wants it higher)

MCV: 98.5 fL (HIGH - heavily penalizing me)

RDW: 18.4% (HIGH - absolutely destroying my score)

ALP: 64.8 U/L (Optimal)

WBC: 7.4 x10\^9/L (Normal)

Is it actually possible to bring my PhenoAge down to ~21? If Yes, How much time would it take for me to get it down to 21?

What is the ultimate "work hard" protocol? I will change my diet, take the right methylated supplements, lift weights, do Zone 2 cardio, whatever you say. Give me the brutal, no-sugarcoating truth on how to fix these specific biomarkers.


r/blueprint_ 2d ago

PAI-1 Impacts Telomere Length, Cell Senescence, And Longevity

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3 Upvotes

r/blueprint_ 3d ago

NAC, Ginger, Curcumin is now gone from the Blueprint store

23 Upvotes

Bryan reportedly stopped taking NAC, Ginger and Curcumin a while ago, and as of now it seems that it has been phased out of not just his protocol, but also the actual blueprint website.

If anyone has any information on this, that could help clarify what happened to this supplement, it would be greatly appreciated.


r/blueprint_ 2d ago

new bryan song

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0 Upvotes

r/blueprint_ 4d ago

What have you added that isn’t on Bryan’s list, and why?

15 Upvotes

The protocol is exhaustively documented, which makes the additions people make on their own more interesting than the parts they copy. Whatever you added presumably reflects either a personal marker, a piece of research he hasn’t weighted the same way, or a bet on something newer. What went in, and has anything you added earned its place?


r/blueprint_ 4d ago

How do you decide anything when the evidence is still early?

5 Upvotes

The uncomfortable middle is a compound with plausible mechanism, promising early data, and no long term human outcomes. Waiting for certainty means waiting a decade. Acting early means being the experiment. I don't think there's a clean answer but I'd like to hear how people actually make the call. Do you set a threshold, cap how many unproven things you'll run at once, or something else?


r/blueprint_ 4d ago

EMF Studies

2 Upvotes

A While back Bryan mentioned that he was going to do research on EMF and its effects on the body, sleep, and overall health. I have not seen or heard anything else about it since and was wondering if he has released any of that data or recommended specific studies other than having the Wi-Fi router outside of the bedroom?

Thanks!


r/blueprint_ 4d ago

How does Bryan Johnson put hemp seeds in super veggie?

3 Upvotes

Soaked/unsoaked or hulled (hemp hearts)whole


r/blueprint_ 5d ago

Are your blueberries and strawberries full of pesticides?

33 Upvotes

More perfect union recently did this video documentary on driscolls farms.
They uncovered that many of the berries that are commercially available in grocery stores in america are above legal limits for cancer causing pesticides, especially those that went to canada. With the fda regulations being more lax than ever before, are you switching your fruit consumption to something not number 1 on the environmental working group’s dirty dozen list? If so what?

strawberry farms and pesticides


r/blueprint_ 7d ago

Nutty pudding and rest of diet still the same?

7 Upvotes

Hi,

I have not been following this in the last year. I miss the nutty pudding stuff. Do they still sell that?
and is the rest of Bryan's current diet pretty much the same?

seeds nuts protein chocolate berries for breakfast

greens and beans lunch

greens and sweet potato and more lentils dinner more or less or are there big changes?

I see his meals have more variety now with the chef and photos but wondering if the breakdown is the same? still no grain?

thanks!


r/blueprint_ 8d ago

7 reasons why female health is decades behind...

58 Upvotes

If you’re a woman…

…with high cholesterol
…in your 30s
…you may be misdiagnosed

In one study, ~6% of women were labeled with high cholesterol… when they were tested again later in their cycle, their results came back ‘normal’.

First half of cycle = higher.
Second half of cycle = lower.

Your cholesterol can swing by 19% depending on the day you get your blood drawn.

It moves monthly with your hormones. In the first half of your cycle, your cholesterol reads high. After ovulation, it falls, hitting its lowest right before your period starts.

When I found this out, I was shocked.

Why does no one know this?

The answer took me down a rabbit hole.

When your blood lab results come back, there’s a “normal range” printed next to each number. That range is created by measuring a big group of people, and calling the middle ‘normal.’

But for decades of blood draws, cycle days weren’t recorded… so their cholesterol variation was invisible.

Then, it got worse in 1977 when the FDA excluded women of childbearing age from early drug trials for 16 years.

So it wasn’t until 2010 when the first rigorous, large-scale proof came back that cholesterol changes with the cycle. A female health study looked at blood biomarkers and compared them with cycle data.

It took 60 years to figure that out.

And yet, it’s 2026, another 16 years later, and the reference ranges are still outdated.

So… why hasn’t this been fixed?

Here are 7 reasons why…

And all of them are easy to fix

#1.
Most doctors don’t know. It is not in their training or guidelines.

#2.
The lab companies haven’t built for it. There’s nothing stopping blood collection companies ( like Quest or LabCorp) from adding this. They set their own systems… they just haven’t prioritized it. And the individual who takes your blood has nowhere to note what cycle day you’re on.

#3.
Self-reported Cycle days. Most women were never taught to track their cycles. The education is thin, and full of myths (most women don’t ovulate on day 14). Even a woman who tracks carefully may have imperfect information. For example, ovulation shifts month to month, and sometimes it’s skipped.

#4 
You can confirm cycle phase with a blood or urine hormone measurement alongside the draw. It’s just that nobody has added this step.

#5.
The data already exists. The 2010 study measured hormones and cholesterol across hundreds of women’s cycles. That’s enough to build a first version of phase-specific ranges. Validating it at scale would take more data, but collecting it is now trivially cheap.

#6.
We repeat the test, but still ignore the cycle. Cholesterol is often checked more than once, which can help smooth out biological variation. But those repeat tests usually aren't timed to the menstrual cycle.

#7.
Ranges only change when someone decides to change them. There's no central body that sets reference ranges... each lab company adopts and verifies its own. When pediatric ranges turned out to be wrong, a research group rebuilt them from thousands of healthy kids and labs adopted the results. The same thing could be done here. It's just that no one has started.

The data to fix this is completely collectible.

A third of American women already track their cycles on their phones.…. and the biobanks have millions of cholesterol results. Nobody has put the two halves together.

Insanely… cholesterol is not the only marker that varies across your cycle. In one study, about 50% of the molecules measured in women’s blood and urine moved with the cycle. And yet… it’s still almost entirely unknown.

So I am running my own experiment…

I’m collecting 14 million data points on my menstrual cycle... my brain, blood, skin, saliva, grip strength, etc. We’re spending $2.6 million on this.
This will be the most quantified menstrual cycle ever.

We’ll post all results here (good and bad, wins and failures) with you for free.... sharing all the practical insights.

My hope is that we can put words and numbers to the female experience.


r/blueprint_ 9d ago

High-Intensity Exercise Triggers a Far Larger Molecular Response Than Moderate Exercise. Five Minutes of Sprints Changed 714 Blood Proteins to Moderate Cycling's 7

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46 Upvotes

r/blueprint_ 9d ago

Mitochondrial Transplantation Rejuvenates Immune Cells

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4 Upvotes

r/blueprint_ 10d ago

Is omega 3 really that important?

8 Upvotes

I hear mix things on the supplements some people say it’s essential especially for brain health other people don’t. Anyone has studied this extensively?