TL;DR: Amicia and Sophia find the next Carrier, Eli, who has been living with his older brother Mark after their parents were killed during an outbreak caused by Eli's Macula. Mark dies protecting him, leaving Amicia to become his new Protector. As the three travel together, Eli's condition worsens and the rat plague evolves into something that could consume the world. They eventually discover a way to destroy the Macula permanently, but it comes at the cost of a human life. Everything seems to point toward Amicia, until the game reveals that Sophia has already made a different choice.
I've been thinking about where A Plague Tale could go after Requiem, and if Amicia's story ever gets a proper conclusion, I'd want it to actually end the cycle rather than just introduce another Carrier.
After Requiem, Amicia and Sophia continue searching for the next Carrier. Eventually they find Eli, a young boy who's been living with his older brother Mark.
Their parents were killed during an outbreak caused by Eli's first major Macula manifestation. Mark never blamed him and basically raised him afterwards. He's Eli's older brother, Protector and only family.
When their hiding place is discovered, Mark gets Eli to safety but dies in the process.
Eli is left completely alone, and Amicia takes on the responsibility of protecting him. Naturally, he doesn't just accept her. Mark was the person who raised him, and Amicia can't simply replace that.
The relationship between the three develops gradually. Sophia is able to bring some normality back into Eli's life, while Amicia becomes increasingly protective of him. There are also moments where Amicia catches herself seeing Hugo in Eli, something she eventually has to confront.
Eli has his own demons as well. His parents' deaths were connected to his first Macula manifestation, and he's spent years believing that he was responsible. Mark was the one person who kept him from completely believing that.
As Eli's Macula develops, Sophia's own history starts becoming relevant. She recognizes certain things happening to him that Amicia doesn't, although she doesn't necessarily explain everything she knows.
Then the situation gets out of control.
We've already seen what the Macula can become at its final stage through Hugo. With Eli, the consequences could be even worse. The outbreaks become increasingly severe, the rats begin adapting, and eventually sunlight may no longer be enough to stop them.
The entire world is running out of time.
Eventually, they discover a way to destroy the Macula completely.
Not transfer it, not suppress it but to end it and there's a price. The process requires a human sacrifice, although the exact conditions aren't immediately clear.
Eli naturally assumes he's the one who has to die. Amicia refuses to accept that, and as they investigate further, they discover that the Carrier actually has to survive for the cure to work which obviously leaves Amicia and this is where I think the game could really mess with the player.
Everything would point toward Amicia sacrificing herself. She's the Protector, she's already lost Hugo, and by this point Eli has become someone she would do absolutely anything to save.
I would let the game reinforce that assumption right up until the final sequence.
Maybe Amicia even gets a proper moment with Eli beforehand. She thinks she's saying goodbye. The player thinks they're watching the end of her story.
Then, at the last moment, Sophia reveals that she's already figured out what the sacrifice requires and she has made her decision.
Not because she's suddenly the "chosen one" or because the story conveniently needs her to die. She's simply decided that Amicia has already given enough.
By this point, Eli means far more to Sophia than just another Carrier she's helping protect. Their relationship has developed naturally throughout the journey, and losing him to the Macula would mean watching another child go through the same fate she has spent the entire game trying to prevent.
So Sophia takes Amicia's place.
I wouldn't foreshadow this with obvious conversations about sacrifice or death. If anything, Sophia should appear completely normal right up until the reveal. The little things she does for Eli throughout the game only become meaningful afterwards.
The final scene between the three should be emotional, but restrained. Amicia realizes what's happening and tries to stop Sophia. Eli does too.
Sophia still goes through with it.
The Macula is destroyed, the plague ends, and there is finally no next Carrier.
Amicia survives.
Years later, Eli is grown and the world is recovering. Amicia and Eli visit Sophia's grave, and Eli leaves behind a small keepsake Sophia gave him earlier in the game.
Then they leave and that's it.
If A Plague Tale is going to end with Amicia, I think this would be a fitting way to do it. She doesn't die repeating the same sacrifice she made for Hugo. She survives, raises Eli, and finally gets to see the cycle end.
No more Carriers.
Lmk your thoughts and opinions in the comments.