After a four year battle with my GP - I finally got my PCOS diagnosis today.

I changed GP and found one that listened and heard me and wanted to work with me not against me.

I feel so many different emotions today, happy to finally have some answers, scared of what’s to come, angry that it’s taken four years to get to this point and a bit of everything else in between.

My GP has recommended metformin which I start tomorrow, and honestly I’m terrified.

I’ve tried to avoid the horror stories and just focus on what it can do for me - i.e. hopefully help with ovulation and TTC.

I’m not eligible right now for any help in the way of ovulation meds like clomid and the like as my BMI is too high so I’m hoping the metformin might help with this alongside calorie counting and exercise.

Does anyone have any success stories with PCOS/metformin/TTC and everything else as I don’t have anyone else to talk to and never had any experience with PCOS so just looking for some tips tricks and a friendly face to talk through it all with!

Hey, everybody! long time reader, first time poster. Just looking for stories, if anyone can relate, or been through it and can say it gets better. I feel insane and it would be nice to know i'm not the only one.

I feel really low, no motivation, a sadness that grips my heart most of the day. Obviously i know TTC is also a life factor that can make people sad, but this "nothing matters" feeling is new and reaches beyond my feelings about TTC. It's really effecting my work.

My question: in anyone else's experience, did the letrozole depression last all month? if so, when did it start letting up after you stopped taking it? I talked to my doctor and she said symptoms should usually only be the first half of the cycle but that hasn't been my experience lmao, and it's making me feel more insane to have her say that because i feel insane!

Also sorry I know stand alone posts about letrozole can be repetitive but I have read every letrozole post I could find on reddit and haven't found anyone discussing symptom length yet. thank you for reading!

This will be a bit long, but please stick around and read :) Some backstory on our fertility journey so far:

- stopped taking birth control pill august 2024
- eventually diagnosed with PCOS (anovulatory) March 2025, prescribed metformin
- finally ovulating consistently by September 2025!!
- no success since then
- started seeing a REI in May 2026. Had full fertility workup (bloodwork, ultrasounds, SHG, SA for husband) and everything came back fine besides my PCOS
- diagnosed with unexplained infertility and prescribed letrozole + trigger shot with TI

Fast forward to today, I’m on CD2 and about to start my first round of letrozole (2.5mg) tomorrow and I guess I’m just looking for some of your input if you have done a medicated cycle before - any side effects with letrozole? Did you finally get pregnant? How long were you trying before you started letrozole? Were you ovulating on your own already?

It’s been a long time coming but it’s kinda hitting me that I’m actually starting fertility meds and I just want to hear from others that have gone through it too. Can you please share anything about your experience with letrozole? Thank you for reading 🫶

how do you actually keep track of what is happening?

If one cycle is 35 days, the next is 60, and another period disappears for months, a normal period app can feel almost useless. Do you track dates only, symptoms, spotting, discharge, mood, pain, or anything else?

I’m curious whether anyone has found a simple way to look back and understand their own pattern instead of constantly wondering when the next period is going to show up.

PCOS, 28F, TTC after 19+5 week loss. responding to meds, ovulating, still not conceiving. Is HSG worth it?

Background: I have PCOS with insulin resistance. I conceived in May 2025 on just Letrozole 2.5mg CD4-8 + trigger. Right-sided ovulation, beta positive at 27.5 at 12 DPO. That pregnancy progressed normally to 19+5 weeks and was lost to cervical incompetence — not a miscarriage, not an embryo issue. The baby was healthy.

Since resuming TTC in 2026, I've done three consecutive medicated cycles, all confirmed ovulation with well-timed intercourse, all negative (<0.2 beta):

- June 2026: Letrozole 5mg + 4 IVF-M injections. Right-sided. Follicle 18.5mm, lining 8.5mm. Negative.
- July 2026: Letrozole 7.5mg + 3 injections. Left-sided. Follicle 20mm, lining 8mm. Negative.
- August 2026: Letrozole bookend 10/7.5/7.5/7.5/10mg + 1 injection. Right-sided. Follicle 23.5mm mean, lining 10.5mm (my best ever). Negative.

Here's what's confusing me: my metrics are objectively BETTER now than when I conceived. My follicles are bigger, my lining is thicker, my protocol is more refined. My bloodwork has improved! testosterone down from 71 to 50, LH normalized, AMH down from 13.9 to 10.6 (metformin effect). I'm on CoQ10 600mg, myo-inositol 4g, levothyroxine (TSH was 2.94, was 2.30 when I conceived). Insulin resistance is still an issue (fasting insulin 23.7, SHBG 11.2, FAI 16) but it was similar or worse when I actually conceived.

My doctor wants to do an HSG in October. My question is, given that I conceived and carried to nearly 20 weeks just last year (proving at least the right tube was patent), is an HSG even necessary? Can tubes get blocked in a year with no surgery, no PID, no STIs? The only thing that happened was a cervical infection (E. faecalis) because my cervix was open during the loss, treated with antibiotics.

Or is this just the numbers game and I need to keep going?

Would love to hear from anyone who conceived previously, had a loss, and then struggled with subsequent cycles despite good response to medication.

Planning to TTC in 12 months from now.

I have lean PCOS — age 24, optimal BMI, no insulin/androgen issues, but ovulation issues. No other fertility factors.

Specialist recommended trying for a maximum of 6 months given my ovulation issues before starting letrozole + monitored cycles, given the ovulation issues. I am wondering if anyone in my situation has had success with letrozole and if so how many cycles did it take to conceive. Feeling very nervous for the uncertain future and trying to be hopeful.

Also anything recommended to prepare during this year leading up?

We’ e been TTC for 15 months. It’s been a long journey of tests, cysts, back tracking, and all the things. You guys get it. We just completed our third round of Letrozole 7.5. I’ve ovulated with good progesterone numbers each time, but today is 11 DPO AND I’m still testing negative. My temp is creeping downward. I’m just sad. Starting Letrozole felt like a step in the right direction but it’s still not resulting in a pregnancy.

Anyone have luck on Letrozole after cycle 3? I’m losing hope.

Hi everyone. I’m having a vvv unusual cycle right now. So I have pcos and I’ve had medicated cycles before . I had 2 letrozole cycles with 2.5mg , with gonal f added and ovidrel . First cycle last year July was cd 3-7, one follicle , gonal f and ovidrel , didn’t work. Second cycle 2.5mg letrozole, cd5-9 August , 2 follicles , gonal f , ovidrel and I got pregnant with a singleton which unfortunately ended in a stillborn early this year. Currently this is my first month trying again and I had a baseline ultrasound and labs done and my labs came back in range of what they want but my ultrasound was very usual. I had my baseline down around cd4 and my lining came back at 10.3mm triliminar (3 stripes) and they told me that was very thick. For reference, last year with the cycle I got pregnant with my daughter , mi baseline was cd 3 n my lining was 3.6mm so this is vvv different .
They gave me 25mg of clomid (half the pill) cycle day4, N I have a follow up ultrasound on cd 11.

I’m just wondering if anyone experienced this before, how did that cycle turn out ?

For those of you on Metformin, did your doc/RE prescribe it to you with your PCOS diagnosis alone or did they run your HbA1c, fasting glucose/insulin? If those things were normal and you were still given it, what were some of the reasons your doc still thought it would be a good fit?

All my numbers came back within normal range but my HbA1c is 5.5, right on the border of “at risk” and I really want to optimize this. I weight about 124lbs, 5’3, menstrual cycle 28-29 days, acne, high follicle count, 36 years old. Started myo-inositol

This is my first cycle on Letrozole 5mg CD3-7 then I take progesterone 200mg starting post peak day 3 for 10 days. On CD 14-16 I spotted no fertile mucus and no lh peak. Finally on CD19 I started having the fertile mucus and a positive lh test on CD 20 so I’m assuming I ovulated around CD21. Starting on CD 22 the spotting came back until I started the progesterone. It quit for a couple days now I am 6-7 DPO and the spotting has returned again this time heavier. Has anyone had this much spotting happen and end up with a successful pregnancy? I was really hoping this cycle would be it!

Adding I conceived my son on 2.5mg letrozole/ progesterone so I was really hoping it would work again. First cycle this time I didn’t respond to the 2.5 until CD28 and my doctor said that was way too late.

Hey everyone!

I took 5 mg of Letrozole from Cycle Day 2–6, and I’m currently on Day 9. I’m still having very light bleeding/spotting.

I also had taken Medrox (medroxyprogesterone) to induce my period cycle last month, so I’m wondering if that makes any difference.

When did you start having sex after taking Letrozole?

Should I start now, or wait until the bleeding completely stops?

Thanks! ❤️

ovulated after taking clomid, pos pregnancy test 9-10 dpo, rising hcg and progesterone then resulted in chemical pregnancy around 6 weeks. it’s been over three weeks since chemical pregnancy— do we think i ovulated on cd24?? pos ovulation test cd22 and 23. temp only rose CD 25 and 26

I’d love to receive honest feedback here. I’m a 30YOF.

I have PMOS & endometriosis noted primarily on the left side of my uterus. I was on a GLP-1 last year, lost 70 pounds, went off of it (before we knew about the PMOS), gained 50 back while TTC. I am now back on a GLP-1, and I’ve lost 13 pounds so far, but this caused us to put a pause on TTC. A part of me wants to keep trying while on the GLP-1 short term because I’m scared I’m wasting time. The plan is a GLP-1 til November with hopefully another 15-20lbs off and transitioning to metformin.

I don’t know anyone with similar health conditions as myself and this. My best friend got pregnant on her first try. I’d really appreciate hearing your opinions on staying the course and holding off while on a GLP-1, or if we should just try because of time ticking by… appreciate any feedback.

I have PCOS (obviously) and I just randomly quit ovulating and getting my regular cycle. The only test that’s come back out of range is my testosterone. We tested everything, even have done an HSG and pelvic ultrasound. I haven’t spoken to my doctor, but is it okay to still taken Letrozole? Has anyone taken it with an elevated number like this and it work out? I don’t have any active cysts, no pain. The annovulatory cycles and fatigue are really my only symptoms. Is this just normal range for PCOS?

Hello! I will be doing my first IUI this week!
I want to hear success stories of IUI as well as what gender you had (heard IUI favors mostly boys)? I don’t care what we get as long as it’s healthy and we are successfully able to conceive!