Hello there, my wife is really quite picky about what she enjoys, and it's been quite hard to find a new show to watch. I'm out of ideas on Disney+ and Crunchyroll for now.
What she likes: mystery, romance, comedy, friendship
What she doesn't like : High tension, horror, violence, emotional conflicts, unlikeable characters, quirky things, anything contemplative, esoteric spirituality, shows where you need to watch more than the first episode to get into.
I'll watch anything she enjoys honestly, except things that drag on forever (no shonen anime with 1000+ episodes)
Series that we loved: only murders in the building, Brooklyn 99, Avatar the last Airbender, star trek deep space nine, The Mandalorian , One Pièce Netflix live action, a bunch of slice of life anime.
Weirdly, Andor worked. Anime is totally possible.
What didn't work : prison break(too much tension), any other star wars stuff, frieren (too completative), firefly (annoying characters, too much tension), Battlestar Galactica (too much tension, quite justified), stranger things (horror and weird), breaking bad (tension), the office (too weird), and I can't remember everything we've tried.
It's very hard to anticipate if something will work or not, but if you like the list we did and didn't like what she didn't, maybe you can help!